洋地黄对病态窦房结功能的影响

The effect of glycosides on sinus node dysfunction

对20例病窦患者用心内调搏方法测定并比较静注西地兰0.5mg 前、后窦房结功能的窦性周期长度、SNRT、CSNRT、TRT,SRT 比值、SACT 及继发性抑制等指标。结果是注药前后各参数均值都无显著改变;其中6例在快速调搏中止后出现继发抑制现象,此6例中的6例周期长度呈成倍延长,注药后4例出现明显的抑制加重;1例 SACT 较前显著延长。提示通常治疗剂量洋地黄并不使病窦自律性抑制加重;对窦房阻滞者需在心内调搏测试后应用。

20 patients with symptomatic sick sinus syndrome(SSS)underwent programmed atrial stimulation for evaluation of sinus node dysfunction hefore and after intravenous injec- tion of cedilanid.Sinus cycle length(SCL),sinus node recovery time(SNRT,CSNRT),total recovery time,SNRT/SCL,secondary pause and sinoatrial conduction time were tested.After cedilanid none of these showed significant change except secondary pause prolonged in patients with sino-atrial block.The results suggested that glycosides may be used safely in SSS patie- nts without disturbance of sino-atrial conduction.