摘要
应用硝苯吡啶治疗心力衰竭96例,总有效率93.7%。疗效:急性左心衰见效快,全心衰、慢性右心衰见效较慢。治疗后血压、心率均有不同程度下降,心搏量及心排血量增加,外周阻力、平均动脉压下降,心功能、心肌缺血均有改善。本药未见严重不良副作用。随访33例病情稳定。硝苯吡啶通过在平滑肌兴奋-收缩耦联中对抗钙离子,从而扩张冠状动脉、外周阻力血管和小静脉,减轻心脏前后负荷,主要为后负荷。增加每搏(?)出量,减少左室舒张末期充盈容量及压力,改善心功能。另外硝苯吡啶强烈扩张周围血管,激发交感神经反射,增加心脏收缩力,使心脏血流动力学变为低阻力一高排血量,因此用于治疗心衰。
96 patients with heart failure were treated with nifedipine. Total effective rate was 93.7 percent. The effct of drug on acute left heart failure was quickly and on whole heart failure or chronic right heart failure was slowly.After treatment,blood pressure,heart rate, peripheral resistance and arterial mean pressure were decreased,heart stroke volume and heart output were increased, heart function as weell as myocardial ischemia were improved.The serious side effects of drug were not found. The mechanism of nifedipine action is to antagonize calcium ions in excitation-contraction coupling.So the coronal arteriae, periphery resistant vessels and small veins are expanded and heart preload and afterload are declined.
