TRH对犬重度失血性休克的拮抗作用

Effects of Thyrotropin-releasing Hormone on Canine Severe Hemorrhagic Shock

以犬重度失血性休克为动物模型,静脉注射促甲状腺素释放激素(TRH,总量5 mg/kg),观察其对动物存活时间、血流动力学、酸碱平衡和肝细胞超微结构等的影响。结果显示:TRH能有效地升高和维持休克犬的平均动脉压(MAP)(治疗4 h后MAP为13.99±0.62 kPa,对照组只有5.09±1.05 kPa),显著延长犬的存活时间,维持酸碱平衡,稳定肝细胞的亚细胞结构。提示TRH具有逆转重度失血性休克的良好作用。

The effects of thy rotropin-releasing hormone (TRH) on survival time, hemodynamics, acid-base balance and subcellular structure of liver cells in canine severe hemorrhagic shock were studied. The results showed that: (1) TRH significantly elevated and maintained mean arterial pressure (MAP) of dogs during shock (MAP was 13.99 ± 0.62 kPa at 4 h after treatment vs 5.09± 105 kPa in control); (2) TRH significantly prolonged the survival time of dogs (alive/total = 4/5 vs 1/5); (3) TRH effectively maintained acid-base balance; and (4) TRH maintained the integrity of subcellular structure of the liver cells. These results suggest that TRH may reverse severe hemorrhagic shock.