摘要
采用检测小鼠血浆和肝脏超氧化物歧化酶 (SOD)、过氧化氢酶 (CAT)和丙二醛 (MDA)的方法 ,观察半叶马尾藻多糖 [Sargassum hemiphyllum (Turner) C.Ag. polysaccharides,SHP]对2 Gyγ射线损伤小鼠氧化自由基的影响。结果发现 2 0 mg/ kg和 4 0 mg/ kg的 SHP不仅能明显降低辐射损伤小鼠血清和肝脏的 MDA含量 ,而且能够提高辐射损伤小鼠 SOD和 CAT的活性 ,并呈剂量依赖性增强。 1 0 mg/ kg的 SHP对辐射损伤小鼠肝脏 SOD、小鼠血浆和肝脏 CAT也有明显的促进作用。
To observe the effect of Sargassum Hemiphyllum polysaccharides (SHP) onthe oxidative damage we detected the activity of superoxide dismutase(SOD), catalase(CAT) and malonaldehyde(MDA) in the plasma and liver of radiated mice of 2 Gy γ rays. It is found that SHP(20mg/kg and 40mg/kg) can not only significantly(P<0.01) decrease the MDA content but also significantly(P<0.01) increase the activity of SOD and CAT in the plasma and liver in a dose dependent manner. SHP(10mg/kg) also significantly increase the activity of SOD in the liver and the activity of CAT in the plasma and liver of radiated mice. The results show that SHP have an inhibitory effect on lipid peroxidation and a free radical clearance effect in radiated mice.
出处
《中国海洋大学学报(自然科学版)》
CAS
CSCD
北大核心
2004年第4期589-593,共5页
Periodical of Ocean University of China
基金
广东省湛江市科技重点攻关项目 (994 5 )资助
关键词
半叶马尾藻多糖
Γ射线
辐射损伤
SOD
CAT
MDA
Sargassum Hemiphyllum polysaccharides (SHP)
γ rays
superoxide dismutase(SOD)
catalase(CAT)
malonaldehyde(MDA)