Ras P_(21)在胰腺癌组织中的表达及其临床病理学意义

Immunohistochemical Detection of ras P_(21) Expression in Pancreatic Adenocarcinoma and Its Clinicopathological Significance

应用免疫组化方法检测了ras P_(21)在43例胰腺癌组织中的表达情况。结果表明:ras P_(21)单抗在胰腺癌组织中的染色阳性率为55.8％,ras P_(21)单抗的染色阳性率与胰腺癌的组织学分化程度和临床分期均有一定关系。经Kaplan-Meier生存率曲线比较和Log-rant检验结果显示:ras P_(21)单抗染色阳性组胰腺癌的预后优于染色阴性组。提示:ras P_(21)的表达主要发生于胰腺癌的早期,而对于肿瘤的进展作用甚少。

By using antr-ras P21 mouse monoclonal (MoAb), SCI-Oncogema 1, the authors examined immunohistochemica! staining in pancreatc adeocarcinoma. The percentage of positive staining was 24/43 (558%). Furthermore it was indicated that the positive staining rate of antr-ras P21 MoAb was related to either histopathological grade or clinical stage. Upon statistical analysis of the correlation between the staining of anti-ras P21 and patient prognosis with Kaplan-Meier curve and Log-rant test, the positive staining cases showed comparatively better prognosis than the negative ones. Our study suggests that ras P21 expression may be important in the early stage of pancreatic carcinoma.