高血压病患者血浆某些神经肽含量的变化

Plasma Levels of Some Neuropeptides in Patients with Primary Hypertension

应用放免法测定了60名正常人和120例高血压病患者血浆β内啡肽(β-EP),亮啡肽(L-EK),神经降压肽(NT)、精氨酸升压素(AVP)、肾素活性(PRA)和血管紧张素Ⅱ(AT Ⅱ)含量。结果发现高血压病患者血浆β-EP和L-EK含量明显降低(P<0.01),血浆AVP、PRA和AT Ⅱ水平明显升高(P<0.01,P<0.05,P<0.05),NT含量与正常组无明显差别。血浆L-EK与平均动脉压呈负相关(r=-0.196,P<0.05),而AVP与病程呈正相关(r=0.216,P<0.05)。结果提示,某些神经肽的分泌异常可能参与高血压病的形成和维持。

Plasma concentrations of β-endorphin (β-EP), leucine enkephalin (L-EK), neurotensin (NT), arginine vasopressin (AVP), renin activity (PRA) and angiotensin Ⅱ (AT Ⅱ ) were measured by radioimmunoassay in 60 normal persons and 120 hypertensive patients. There were lower levels of β-EP and L-EK (P<0.01), and higher levels of AVP, PRA and AT Ⅱ (P<0.01 ,P<0.05 and P<0.05, respectively), and normal level of NT in the patient group as compared with those in the normal group. Plasma level of L-EK was correlated negatively to mean artery pressure (r= -0.196, p<0.05). Plasma level of AVP was correlated to the duration of the hypertension (r= 0.216, P< 0.05). These results indicate that the changes of secreation of some neuropeptides may contribute to the development and maintenance of hypertension.