精氨酸加压素抗血清对急性心肌缺血大鼠心功能的影响

The Effect of Arginine Vasopressin on Cardiac Function in Rats with Acute Myocardial Ischemia

结扎大鼠左冠状动脉前降支形成急性心肌缺血后,血液、垂体、部分脑区及心肌组织中,精氨酸加压素(AVP)免疫活性物质含量明显升高,并伴有心肌收缩力减弱、左心室内压最大上升速率降低、左心室内堆峰值下降与血压降低等心功能抑制的变化;光镜观察可见,冠脉结扎2h后,心肌间质轻度充血及出血灶,静脉给予AVP抗血清,则可改善和延缓心功能的恶化;心肌间质充血程度减轻,未见明显出血灶。提示AVP参与了大鼠急性心肌缺血的病理过程。

In this study, Iigation of the anterior descending branch of the left coronary artery was used to produce acute myocardial ischemia in rats. Radioimmunoassay was performed to determine the dynamic changes of immunoreactive arginine vasopressin (ir-AVP) content after ischemia. Results showed that levels of ir-AVP of the plasma, some brain areas, pituitary and myocardium were markedly increased post-ischemia. Meanwhile the left ventricular myocardial contractility parameters such as dp/dtmax, ventricular systolic pressure and blood pressure were markedly decreased. Intravenous injection of anti-AVP serum 30 min before ligation could improve the function of the heart. Under light microscope, there were slight congestion and focal bleeding in the myocardial mesenchyma 2 h after coronary ligation and these changes were minimized or vanished with the use of anti-AVP serum before coronary Iigation.