冬虫夏草对大鼠小剂量环孢素A慢性肾毒性保护作用的实验研究

Experimental Study on the Protection of Cordyceps Sinensis to Cydosporine A Nephrotoxicity

为进一步探讨冬虫夏草(Cordyceps Sinensis)对环孢素A(Cyclosporine A,CsA)慢性肾毒性的保护作用和机制,将SD大鼠分为两组:CsA组和CsA+冬虫夏草组,实验3个月。结果显示:在实验不同时期冬虫夏草组大鼠血Cr、BUN及血清Na^+、K^+均较对照组为低,实验第3月冬虫夏草组鼠血清血管紧张素Ⅱ(AT-Ⅱ)水平低于对照组;实验不同阶段尿EGF排出量亦较对照组为低;肾组织病理形态改变较对照组明显为轻。本实验证明冬虫夏草对CsA慢性肾毒性有明显保护作用,能减轻肾小管细胞损伤并促进其病变修复,可能对肾血流动力学的改善亦有一定作用。

In order to further explore the protective effect of Cordyceps Sinensis (CS) on Cyclosponne A nephrotoxicity (CsA-Nx) and its possible mechanisms, SD rats were divided into two groups: CsA group and CsA + CS group. The results showed that: in different experiment period, serum BUN. Cr, Na. K and urine EOF excretion in CS group were lower than that in control group. In the third month, serum AT- |J in CS group was also lower than that in control group. Pathological examination showed that CS could protect the kidney from CsA-Nx and ameliorate the glomerular and interstitial injuries. It suggests that CS could protect the kidney from CsA-Nx, especially protect the proximal tubular function and ameliorate renal hemodynamics.