乳清酸对急性心肌梗塞后非梗塞区心肌的保护作用

Protective Effect of Orotic Acid on Noninfarcted Myocardium after Acute Myoeardial Infarction

本研究观察了大鼠急性心肌梗塞(AMI)经乳清酸治疗(AMIOA)和生理盐水治疗(AMINS)后梗塞面积、非梗塞区心肌肥大及能量的改变。结果表明:在AMI后1,3,7,14d,AMIOA与AMINS组梗塞面积无明显区别(P>0.05);在AMI后14d,AMIOA组大鼠体重明显高于AMINS组(P<0.05);梗塞后7,14d,AMIOA、AMINS两组全心重量、右室重量体重比、心脏重量/体重比相近,但高于假手术组(SONS)(P<0.05);AMIOA组非梗塞区心肌ATP、CP含量高于AMINS组(P<0.01～0.05),与SONS组相近(P>0.05)。提示:乳清酸治疗AMI,不扩大心肌梗塞面积,且有利于体重的恢复,改善非梗塞区能量代谢。

The changes of infarct size as well as compensatory hypertrophy and ATP. CP contents on noninfarcted myocardium of rats were observed both in AMIOA (acute myoeardial infarction treated with orotic acid) and AM1NS group (acute myoeardial infaraction treated with 0.9% sodium choride solution). On days 1. 3, 7, 14 after AMI, infarct size in AMIOA group showed no evident difference from those in AM1NS group (P>().O5). On day 14, rat weight in AMIOA group was greater than that in AM1NS group (P<0.05). On days 7. 14. heart weight, heart weight/body weight and right ventricular weight/body weight were similar between this two groups (P<0.05), greater than those in SONA group (sham-operauon treated with 0.9% sodium cloride solution (P<0.05). ATP, CP contents in AMIOA group increased more than those in AMINS group (P< 0.01, P<0.05) and similar to those in SONS group (P>0. 05) These results indicates that orotic acid not only could not enlarge infarct size, but also is benifiual to body weight recovery and could improved energy metabolism on noninfarcted myocardium.