膀胱癌ABH血型物质与病理分级、生物学行为的关系

The relationship of ABH blood antigens with pathological grading and prognosis of transitional-cell carcinoma of the urinary bladder

本文报告用ABC法对100例膀胱移行细胞癌切片进行ABH单克隆抗体标记,并进行了随访。结果显示:抗原检出率为63％,其中阳性组3年内死亡及随访期间复发人数明显低于阴性组(P<0.01),5年以上生存无复发人数明显高于阴性组(P<0.01)。低分化癌组中抗原阳性病例亦表现出比阴性更好的预后(P<0.05)。我们认为,血型物质表达与预后的关系优于形态分级,是种比较理想的膀胱癌免疫标记物。

The expression of A,B and H blood antigens were studied in 100 sepcimens of transitional-cell carcinoma with monoclonal antibodies and ABC immunohisto-chemical assay.And the patients were followed up.It was found that A,B and H antigens were positive in 63% of the cases.The rates of mortality and ecurrence were lower in the positive cases than in the negative ones(P<0.01),the 5-year survival rate was higher in the positive cases than in the negative ones(P<0.01),and the prognosis was better in the former than in the latter(P<0.05).It is believed that the determination of A,B and H antigens is more sensitive for the prognosis of transtional-cell carcinoma than pathological grading or CEA measurement.