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SARS冠状病毒S蛋白的功能性受体-ACE2 被引量：5

Angiotensin-converting Enzyme 2 is a Functional Receptor for the SARS Coronavirus S Proteins
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摘要 SARS冠状病毒的棘突S蛋白 ,与细胞受体介导的感染有关。血管紧张素转化酶 2 (ACE2 )是SARS CoVS蛋白的功能性受体 ,人类ACE2酶的细胞外区域由 2个亚基组成 ,其中锌金属肽酶区域可以进一步分成 2个亚域 (I和II) ,形成一个长而深的裂缝 ,环绕裂缝顶端的隆起线可能作为与S 糖蛋白结合的区域。ACE2可以与SARS CoVS蛋白的S3 1 8 5 1 0结合。这将为发展新型SARS疫苗和SARS的预防和治疗提供新的研究方向。 Spike (S) proteins of coronaviruses,that causes severe acute respiratory syndrome (SARS), associate with cellular receptors to mediate infection of their target cells. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. The extracellular region of human ACE2 enzyme is comprised of two domains. The metallopeptidase domain of ACE2 can be further divided into two subdomains (I and II), which form the two sides of a long and deep cleft, the ridges surrounding the cleft at the top of the molecule could serve as a likely binding region for the Sglycoprotein. A 193-amino-acid fragment of the SARS coronavirus S protein (S318-510) efficiently binds angiotensin-converting enzyme 2. These finndings could help in the development of novel vaccine immunogens and therapeutics for prevention and treatment of SARS.
作者 孙琰 柳林 潘欣
机构地区 第二军医大学附属长海医院眼科 第二军医大学微生物教研室
出处 《微生物学杂志》 CAS CSCD 2004年第4期25-30,共6页 Journal of Microbiology
基金 国家重点基础研究发展规划项目 (793计划 ) 课题编号 :2 0 0 3CB5 14 12 9
关键词 SARS冠状病毒S蛋白 血管紧张素转化酶2 受体 SARS-CoV S protein,angiotensin-converting enzyme 2,receptor.
分类号 R373 [医药卫生—病原生物学] S852.65 [农业科学—基础兽医学]
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参考文献23

  • 1Paul Towler1, Bart Staker2, Sridhar G. Prasad2, 3, Saurabh Menon1, Jin Tang4, Thomas Parsons4, Dominic Ryan1, Martin Fisher1, David Williams1, Natalie A. Dales1, Michael A.Patane1, Michael W. ACE2 Suuctures Reveal a Large HingeBending Motion Important for
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同被引文献39

  • 1孔琪,秦川.SARS病毒功能受体ACE2和抗体80R的研究[J].医学研究通讯,2004,33(7):37-38. 被引量：2
  • 2孙琰,潘欣,柳林,倪灿荣.SARS-CoVS蛋白功能性受体ACE2在人、兔角膜、结膜中的表达[J].眼科新进展,2004,24(5):332-336. 被引量：26
  • 3Tipnis SR, Hooper NM, Hyde R, et al. A human homolog of angiotensin convertingenzyme. Cloning and functional expression as a captopril insensitive carboxypeptidnse [ J]. J Biol Chern, 2000, 275(43) : 33238-33243.
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  • 5Harmer D, Gilbert M, Borman R, et al. Quantitative mRNA expression profiling of ACE2, a novel homologue of ACE [J]. FEBS Lett, 2002, 532 (1-2): 107-110.
  • 6Lgase M, Strawn WB, Gallagher PE, et al. Angiotensin Ⅱ ATI receptors regulate ACE2 and angiotensin - ( 1 - 7) expression in aorta of spontaneously hypertensive rats [ J ]. Am J Physiol Heart Circ Physiol, 2005, 289 (3): H1013-1019.
  • 7Ferrario CM , Jessup J, Chappell MC, et al. Effect of angiotensin -converting enzyme inhibition and angiotensin Ⅱ receptor blockers on cardiac angiotensin - converting enzyme 2 [ J ]. Circulation, 2005,111 (20): 2605-2610.
  • 8Ferrario CM, Chappell MG, Tallant EA, et al. Counter regulary action sofangiotensin 1- 7 [J]. Hpertension, 1997, 30 (3 Pt 2):535-541.
  • 9Stegbauer J, Vonend O, Oberhauser V, et al. Effacts of angiotensin ( 1 - 7) and other bioactive components of the renin - angiotensin system on vascular resistance and noradrenaline release in rat kidney[J] . J Hypertension, 2003, 21 (7): 1391-1399.
  • 10Carey RM. Angiotensin type - 1 receptor blockade increases ACE 2 expression in the heart [ J ]. Hypertension, 2004 , 43 (5) : 943-944.

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微生物学杂志
2004年 第4期

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