血清酶在模拟高原条件下的活力变化

Changes of serum enzyme activities of healthy males under simulated high altitudes

本文观察平原和模拟3500m、4500m高原低压实验舱内11名健康男性血清酶CK、LDH、HBDH、AST的活力变化。结果表明酶活力随海拔升高而增高,其显著性顺序为CK、LDH、HBDH,而AST则无统计学意义。CK与LDH比值和心率与海拔增高呈一致的量-效改变,与血氧饱和度和劳动负荷值呈相反的量-效变化;复合锻炼可改善血清酶变化程度恢复至近似平原水平。提示CK和LDH可作为评估人对高原低氧环境的适应能力较好指标。

The changes of the activities of serum CK,LDH,HBKH and AST of 11 soldiers having stayed in simulated 3500m and 4500m were observed.It was found that the activities were significantly increased in the order of CK,LDH and HBDH because of hypoxia but the changes of AST was of no statistical significance.CK/LDH ratio and pulse rate showed similar charges to serum enzymes but the changes of arterial oxygen saturation and working efficiency were the opposite to those of serum enzymes.These findings suggest that serum CK and LDH are the indicators of choice to evaluate human reactions to high altitude.