烧伤后血、尿Tamm-Horsfall蛋白变化的意义

Changes of Tamm-Horsfall protein in the urine and blood of severely burn patients

本文用放免法测定59例严重烧伤病人血尿THP含量并进行动态观察,发现血、尿THP含量明显降低,降低的程度与烧伤严重程度和肾功能损害程度密切相关,与BUN、Cr呈显著负相关,与Ccr呈显著正相关。血、尿THP具有变化幅度大,发生早,组织学分型的血、尿THP对严重烧伤后肾脏髓袢及远曲小管损害具有预警意义。

Tamm-Horsfall protein(THP)was determined with radioimmunoassay in the urine and blood samples of 59 burn patients.It was found that urine and blood THP was significantly decreased postburn and the degree of decresing was correlated with the extent of the burnt body surface and the severity of renal damage.The changes of THP occurred earlier than those of the routine parameters for renal damage such as BUN or Cr.It is suggested that THP determination can be used as an index for the early damage of the Henle's loop and the distal convoluted tubules after burn injury.