磷烧伤预后与清创时间关系的实验研究

A study on the relationship between prognosis and debride-ment time in rats with phosphorus burns

雄性Wistar大白鼠,分为3组,组Ⅰ正常组,组Ⅱ、Ⅲ致成20％和30％磷烧伤;组Ⅱ不清创:组Ⅲ于伤后立即及6 h清创。结果显示:(1)伤后立即清创的28只动物全部活存,6 h清创44只,死亡率为20.5％;组Ⅱ 8只动物,死亡率为37.5％。(2)伤后立即清创组组织磷含量明显降低与其它组差别非常显著(P<0.01)。(3)血清电解质恢复接近正常,生化指标有改善。上述结果表明,伤后“立即清创”是早期有效清创时间。

Male Wistar rats were randomized into 3 groups:The rats of group I received sham burning to serve as the control and those of groups and Ⅲ were inflicted with 20% and 30% TBSA third degree phosphorus burns respectively.No treatment was given to group Ⅱ.Group Ⅲwas further divided into 2:The rats of subgroup Ⅰ were debrided immediately and those of subgroup Ⅱ in the 6th hour postburn.The findings were as follows;(l)The tissue content of phosphorus was more significantly decreased in subgroup Ⅰ than in subgroup Ⅱ-(2)Twenty-eight rats of subgroup Ⅰ all survived while 9 of the 44 rats of subgroup Ⅱ died with a mortality rate of 20.5%.The mortality rate of group Ⅱ was 37.5%(3/8).(3)The recovery of serum electrolytes and other biochemical parameters occurred earlier in subgroup I.Our findings suggest that debridement as early as possible after phosphorus burns contributes significantly to the decrease of the victims mortality.