油酸性犬呼吸窘迫综合征初期血液流变学变化

Early hemorrhelogical changes of oleic acid-induced RDS in dogs

本文观察了油酸性犬呼吸窘迫综合征初期(2 h)的血液流变学变化。其结果是:注射油酸2 h,红细胞压积(HCT)、全血表观粘度(ηa,230.4S^(-1),25℃)、全血相对粘度(ηr)明显增加(P<0.05～0.01),而血浆粘度(ηp)无明显变化(P>0.05);提示油酸性犬呼吸窘迫综合征初期血液流变学改变的特征是血液浓缩,红细胞变形能力降低,可能是RDS发生过程中肺微循环障碍的重要原因之一。

The hemorrheological changes were observed in dogs in the first 2 hours after they were inflicted with oleic acid-induced RDS.It was found that hematocrit,absolute viscosity and relative viscosity of whole blood were significantly increased but plasma viscosity showed no marked changes.These facts imply that in the early stage of oleic acid-induced RDS,the hemorrheological changes were characterized by hemoconcentration and decrease of the trans-formability of erythrocytes,which might be one of causes of the functional failure of pulmonary microcirculation.