摘要
在豚鼠离体主动脉实验中,六甲氧苄嗪(HMZ)随剂量增大,对主动脉的扩张效应亦逐渐增强;而β受体阻滞剂盐酸普萘洛尔则能部分抑制其扩张反应。HMZ对α受体激动剂重洒石酸去甲肾上腺素(NE)和Ca^(2+)的血管收缩效应有明显的抑制作用,效量曲线被压低,表现为非竞争性拮抗。说明HMZ的扩血管作用与α和β受体无明显关系,可能是通过对Ca^(2+)通道的抑制作用使血管扩张,且效应较三甲氧苄嗪(TMZ)明显增强。
It was found that hexametazidine (HMZ, 30μmol/L) could clearly relax smooth muscle in isolated aorta stops of guinea pig. The vasodilative action could be partly inhibit by propranololl which is a β-adrenoceptor antagonist. HMZ caused a pronounced noncompetitive inhibition of vasoconstriction evoked by Ca2+ and noradre-naline (NE). These findings indicated that HMZ cannot be classified either as a α-adrenoceptor blocking agent or as a β-adrenoceptor exciting agent. The mechanism of vasorelaxation could be related to block calcium channel.
出处
《第四军医大学学报》
1993年第4期287-290,共4页
Journal of the Fourth Military Medical University
关键词
六甲氧苄嗪
三甲氧苄嗪
扩血管效应
hexametazidine
trimelazidine
propranololl
noradrenaline
vasorelaxation
