鞠泻片对实验性动脉粥样硬化家兔的影响

Effects of Juxie tablet on experimental atherosclerosis in rabbits

作者观察了动脉粥样硬化家兔体内血脂代谢,血液流变学,MDA与SOD,6-酮基-PGF_(1α)与TXB_2,雌二醇与睾酮的变化及鞠泻片对其影响,结果发现病理组家兔血浆6-酮基-PGF_(1α)为 151.57±74.70 ng/L,TXB_2值为1166.63±554.70 ng/L。鞠泻片治疗组6-酮基-PGF_(1α)为187.60±70.43 ng/L,TXB_2值为270.10±120.40 ng/L,两值平衡恢复。病理组雌二醇为61.90±12.86 ng/L,睾酮值为51.90±44.54 ng/L,治疗组雌二醇为80.28±33.18 ng/L,睾酮值为 88.44±44.65 ng/L。鞠泻片使血脂MDA血粘度降低,提高体内SOD和激素水平,恢复6-酮-PGF_(1α)与TXB_2二者的平衡。

The authors observed in vivo the changes of hemorrheology, blood-lipids metabolism, MDA, SOD, 6-keto-PGF1α,TXB2, estradiol and testosterone in rabbits with laboratory atherosclerosis, and the effects of Juxie tablet on them. It was found that the plasma 6-keto-PGF1α and TXB2 levels in pathological group were 151.57±74.70 ng/L and 1 166.63±554. 70 ng/L respectively. It was obvious that the two levels were out of balance. The plasma 6-keto-PGF1α and TXB2 levels in treatment group (using Juxie tablet) were 187. 60±70. 43 ng/L and 270. 10±120. 40 ng/L respectively, the estradiol and testostrone levels in pathological group were 61. 90±12. 86 ng/L and 51. 90±44. 54 ng/L respectively, while that in treatment group were 80. 28±33. 18 ng/L and 88. 44±44. 65 ng/L, respectively. It indicates that Juxie tablet can lower the levels of blood hpid, MDA and blood viscosity, enhance SOD and hormone levels, and restore the balance between 6-keto-PGF1αand TXB2 levels.