肾功能不全病人使用抗生素的调查分析

Analysis of antibiotic therapy in patients with renal failure

为了解肾功能不全病人的合理用药情况,本文作者对394例肾功能不全病人住院期间使用抗生素作了分析,24.1％的病人并发细菌感染,39.1％的病人使用了抗生素。所用的19种抗生素中肾毒性的抗生素占21.1％,它们是链霉素,庆大霉素,卡那霉素和丁胺卡那霉素、因联合用药对肾功能有损害的抗生素有头孢唑啉,头孢氨苄,头孢拉定,吡哌酸,乙胺丁醇和SMZ+TMP占31.6％。根据肾功能减退而作剂量调整者占50％,作时间调整者占80％,对调查结果作了进一步讨论。

The rational use of antibiotics in 394 inpatients with renal failure was investigated. The results showed that bacterial infection was complicated in 24% of all cases, antibiotics were used in 39.1% of the cases. In the 19 kinds of antibiotics used, 21.1% of which are nephrotoxic. Dosage regimen in 50-80% of the cases had been adjusted according to the severity of renal insufficiency. The results were further discussed.