纳洛酮治疗早产儿原发性呼吸暂停疗效观察

Investigation of the effects of naloxone therapy on primary apnea of prematurity

目的:观察纳洛酮治疗早产儿原发性呼吸暂停的效果。方法:79例患儿随机分成两组,治疗组(n=41)在对照组(n=38)综合治疗的基础上加用纳洛酮0.1mg/(kg·次)静脉注射,3次/d。结果:总有效率治疗组95.1%,对照组73.7%,χ2=7.82,P<0.01。结论:纳洛酮能有效治疗早产儿原发性呼吸暂停。

Objective: To observe the curative effects of naloxone therapy on primary apnea of premature infants. Methods: 79 in-patients diagnosed as premature infant apnea syndrome were randomly divided into treatment group (41 cases) and control group (38 cases). The control group was treated routinely. Besides routine therapy, treatment group were treated with intravenous Naloxone at dose 0.1 mg/kg every time, three times a day. Results: Total curative rate of treatment group is 95.1%, and that of control group is 73.7%. There are significant differences between treatment group and control group( χ2 = 7.82, P < 0.01). Conclusion: Naloxone has postive effects against premature infant apnea syndrome.