哮喘患儿血IL-4及Eotaxin的含量变化及意义

The changes and significance of IL-4 and Eotaxin level in peripheral blood of children with asthma

目的 探讨支气管哮喘患儿血浆白细胞介素 - 4 (IL - 4 ) ,嗜酸性粒细胞趋化蛋白 (Eotaxin)含量的变化及临床意义。方法 采用ELISA法测定 4 7例哮喘患儿 (发作期 2 8例 ,缓解期 19例 )的血IL - 4、Eotaxin的含量 ,并与正常对照儿比较。结果 哮喘发作组、缓解组患儿与正常对照儿的IL - 4含量间差别有显著性意义 (P <0 0 5 ) ;发作组与缓解组患儿的IL - 4含量间差别亦有显著性意义 (P <0 0 5 )。哮喘发作组患儿与缓解组患儿及正常对照儿的Eotaxin含量间差别均有显著性意义 (P <0 0 5 ) ,而缓解组患儿与正常对照儿的Eotaxin含量间差别无显著性意义 (P>0 0 5 )。血IL - 4含量和Eotaxin含量呈正相关 (P <0 0 5 )。结论 哮喘患儿血IL - 4、Eotaxin含量能反应哮喘气道炎症活动情况及疾病的严重程度 ,两者存在正相关。

Objective To evaluate clinical applications of IL-4 and Eotaxin level in peripheral blood in children with asthma.Methods The IL-4 and Eotaxin level in 47 children with asthma was assessed with ELLSA technique.Results The IL-4 level in the asthmatic children with acute attack and in the remission group was much higher than that in normal group(P<0.05), it had significant difference between acute attack group and remission group(P<0.05). The Eotaxin level in the asthmatic children with acute attack was much higher than that in the asthmatic patients in remission(P<0.01) or normal subjects(P<0.001).The Eotaxin level had no obvious difference between the remission group and normal group(P>0.05).Conclusion The IL-4 and Eotaxin level in peripheral blood in children with asthma may reflect the airway inflammation and the severity of disease in asthma, so there was a significant correlation between the IL-4 and Eotaxin level.