肝硬化对病人血液某些金属元素的影响

Effects of liver cirrhosis on some metal elements in whole-blood of patients with liver cirrhosis

目的 :探讨肝硬化对病人全血金属元素含量的影响。方法 :本研究采用电感耦合等离子发射光谱法 ,测定了 5 2名肝硬化病人和 4 4名非肝硬化病人全血中锌 (Zn)、铜 (Cu)、铁 (Fe)、钙 (Ca)、锰 (Mn)和镁 (Mg)含量。结果 :肝硬化病人血锰含量增加 (P <0 .0 1) ,Zn、Fe和Mg含量降低 (P <0 .0 1) ,Cu和Ca含量未见显著性差异。结论 :肝硬化时 ,病人血中金属元素的含量是受到影响的 ,在临床上要注意监测 ,以防止因某些金属元素缺乏和 /或过多而引起并发症。

Objective: To study the effect on some metal elements in whole-blood of patients with liver cirrhosis. Methods: The concentrations of Zn,Cu,Fe,Ca,Mn and Mg were detected with ICP-ES in 52 cases of liver cirrhosis and 44 cases of non-liver cirrhosis as control. Results: Concentrations of Zn、Fe and Mg in patients with liver cirrhosis were lower than those in control(P<0.01), while the concentration of Mn was significantly higher(P<0.01). There were no significantly difference in the concentrations of Cu and Ca between two groups. Conclusion: The concentrations of metal elements in whole-blood of patients with liver cirrhosis were affected during liver cirrhosis. We should pay more attention on such patients that can prevent the complications which may be caused by some metal elements deficiency and/or excess.