摘要
目的 探讨芸香苷 (rutoside,Ru)对大鼠急性胰腺炎(acutepancreatitis,AP)血液流变学的影响。方法 观察各组Wistar大鼠血液流变学、酶学及胰腺的病理学改变 ,并对胰腺病理切片进行评分、对比。结果 AP大鼠全血粘度、血浆粘度、血沉、红细胞压积、红细胞聚集指数、红细胞刚性指数均显著升高 ,病理检查显示胰腺组织明显坏死和炎性细胞浸润。Ru(12 0、6 0、30mg·kg-1)皮下注射给药 (subcutaneousinjection ,sc) ,可改善上述各项病理生理指标。 结论 Ru能有效改善AP大鼠血液流变学异常 ,保护胰腺组织。
AIM To study the effect of rutoside (Ru) on blood rheology in murine acute pancreatitis (AP). METHODS Blood rheology, enzymatic levels and pathology of the pancreas were evaluated in all Wistar rats. The pancreatic sections were scored and compared. RESULTS In AP group, the whole blood viscosity, the plasma viscosity, the eryrocyte sedimentation, the hematocrit, the agglutinatin index of red blood cell, and the rigidity index were significantly elevated. The pancreatitis injury was described as evident pancreatic acinar necrosis and infiltration of inflammatory cells. Ru 120, 60, 30 mg·kg -1 (sc) ameliorated the abovementioned adverse pathophysiological changes seen in the control group. CONCLUSION During the course of AP, rutoside ameliorated the blood rheology abnormality and showed a protective effect on pancreatic tissue.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2004年第6期685-688,共4页
Chinese Pharmacological Bulletin
基金
安徽省科技厅自然科学基金资助课题
No 0 10 43 90 7
安徽省教育厅自然科学基金资助课题
No 2 0 0 1kj12 2
