卵巢粘液性肿瘤组化和免疫组化研究

Histochemical and Immunohistochemical Study of Ovarian Mucinous Tumors

对50例卵巢粘液性肿瘤进行组化和免疫组化研究。良性、交界性和恶性3组肿瘤酸性粘蛋白的含量和粘蛋白的分布范围形成鲜明对比;在甲苯胺蓝异染性方面有明显差异。这对鉴别卵巢粘液性肿瘤良、恶性有参考价值。3组肿瘤免疫组化阳性反应的程度无明显差异,腺癌分化的程度与CEA细胞阳性率不呈正相关。表明CEA染色不能判断卵巢粘液性肿瘤的恶性程度。正常卵巢组织CEA阴性,如果良性肿瘤内CEA含量较多,从生物化学上已暗示可能己越出良性范畴,但在组织学上尚未表现出来。应注意随访。

Fifty cases of ovarian mucinous tumor (23 benign, 13 borderlineand 14 malignant) were studied histochemically and immunohistochemi-cally. The differences of mucoproteinaceous proportion and distributionwere demonstrated in the cells of these tumors. By toluidine blue sta-ining,most cases showed metachromatism .After methylotion (37℃), thisindicates that the metachromatic substance is sialomucin. In ovarianmucinous tumors,sialomucin is increased with the increase of maligna-nt. degree. The CEA stain cannot judge malignant degree of ovarianmucinous tumors.