烧伤患者血浆总IgE的变化

The changes of plasma total IgE concentrations in burn patients

目的 :本研究通过对烧伤病人病程发展中血浆总IgE的跟踪观察 ,探索烧伤病人血浆总IgE的变化规律。方法 :将 87例烧伤病人按面积大小分为三组 ,入院后 1、7、14、2 1d采血检测血浆总IgE ,并抽 2 0名健康人血样作正常对照。结果 :烧伤病人与正常组血浆总IgE有显著差异 (p <0 .0 0 1) ,烧伤病人血浆总IgE三组间重度组与中度组 ,中度组与轻度组有显著差异 (p <0 .0 1) ,烧伤病人治疗过程中血浆总IgE第一周与第二周、第三周有显著差异 (p <0 .0 1) ,第二、三、四周有显著差异 (p <0 .0 1) ,第二、三周无差异 (p >0 .0 5 )。结论 :烧伤病人血浆总IgE的测定 ,可作为烧伤病人病情程度和预后的观察指标 ,有助于对烧伤病人 ,尤其是大面积病人病情的观察、判断和治疗。

Objectives: To explore the relationship between the changes of plasma total IgE concentrations and degree of burns. Methods :87 burn patients were randomly divided in to three groups according to burn area, 20 healthy adults as control. Plasma concentrations of total IgE were detected within 1、7、14、21d after burn. Results: Plasma total IgE concentrations of burn groups significantly increase compared with healthy groups(p<0.001).Obvious difference was found not only between severe and moderate burn groups but also between moderate and slight burn groups(p<0.01).In treatment, among every week except 2nd and 3rd week evident difference was found ,too(p<0.01).Conclusions: Plasma total IgE concentrations may be used to acknowleging degree and prognosis of burn. It also contributes to diagnosis and treatment of burn patients, especially severe burn one.