牛磺酸对慢性肾小球肾炎患者血小板活化因子水平的影响

Effect of taurine on platelet activating factor in patients with chronic glomerulonephritis.

目的 探讨牛磺酸对慢性肾小球肾炎患者血小板活化因子水平的影响及其对肾脏的保护作用。方法 用牛磺酸治疗 12例慢性肾小球肾炎患者 4周 ,采用生物活性法测定治疗前、后血浆及尿中血小板活化因子 (PAF)的含量 ,观察尿蛋白变化及临床表现。结果 经牛磺酸治疗后 ,慢性肾小球肾炎患者尿蛋白下降 ,血浆及尿中PAF显著减少。结论 牛磺酸能减轻慢性肾小球肾炎患者蛋白尿 ,降低血浆及尿中PAF水平 。

Objective To explore the effect of taurine on platelet activating factor(PAF) in patients with chronic glomerulonephritis and its protective effect to venal function.Methods Plasma and urine PAF contents in 22 patients with chronic glomerulonephitis were measured by biological activity methods and urine protein as well as clinical manifestation was observed before and after 4-week treatment with taurine.Results After treatment with taurine,urine protein levels were decreased and plasma and urine PAF were significantly decreased in chronic glomerulonephitis patients.Conclusioin Taurine can lessen proteinuria and lower the PAF level of plasma and urine,exercising certain nephroprotective role in the patients with chronic glomerulonephritis.