妊娠高血压综合征患者血清碱性磷酸酶异常与妊娠结局

Relationship between serum ALP and pregnancy outcome in pregnancy-induced hypertension syndrome women

目的 探讨妊娠高血压综合征患者血清碱性磷酸酶 (AL P)水平异常与妊娠结局之间的相关性。方法 采用 OL YMPUSAu- 2 70 0全自动分析仪检测 1 4 2例妊娠高血压综合征患者的肝肾功能 ,并将 AL P高于正常值者 30例 (A组 )与 AL P正常者 1 1 2例(B组 )的妊娠结局进行对照。结果 A组 AL P、TBIL、DBIL、U A均高于 B组 ,差异有显著性 ;AL T、AST、AL B略高于 B组。A组低体重儿、早产及新生儿青紫窒息的百分率均高于 B组 ,差异有极显著性。 A组重度妊娠高血压综合征所占比例最大 ,轻度妊娠高血压综合征所占比例最小 ,且与 B组比较 ,差异有显著性。结论 AL P水平升高程度反映妊娠高血压综合征病情的严重程度 ,妊娠高血压综合征患者 AL P的变化早于 AL T及 AST,临床可通过对此生化项目的监测来早期诊断 。

Objective To investigate the correlation between serum ALP and pregnancy outcome in patients with pregnancy induced hypertension(PIH) syndrome. Methods OLYMPUS Au 2700 auto analyzer was used to evaluate the biochemical index for liver and kidney functions in 142 PIH patients. The pregnancy outcomes were followed up in 30 patients with elevated ALP (group A), compared with 112 patients with normal ALP (group B). Results The serum level of ALP, TBIL, DBIL, UA in group A were significantly higher than those in group B; while ALT, AST, ALB slightly increased in group A. The percentages of low birth weight infant,premature labour and neonatal blue asphyxia in group A were significantly higher than those in group B. In group A, the constitute ratio of severe PIH was the highest, while the ratio of slight PIH was the lowest. Moreover there were significantly differences between group A and group B.Conclusions The increased level of ALP reflected the severity of the disease. The changes of the level of ALP occurred earlier than ALT and AST, and ALP could be used to make early diagnosis to prevent the occurrence of pregnancy complications.