“抗纤汤”治疗四氯化碳致肝纤维化大鼠模型的实验研究

Study of Kang Xian Soup to prevent liver fibrosis induced by carbon tetrachloride in rats

目的 观察“抗纤汤”对四氯化碳致肝损伤的肝纤维化大鼠模型的治疗效果。方法 6 0只大鼠被随机分为 3组 ,每组 2 0只 ,在治疗组用“抗纤汤”治疗 3个月后分别比较正常对照组、模型组和治疗组大鼠血清谷丙转氨酶 (AL T)、谷草转氨酶 (AST)、 型前胶原 (PC )、透明质酸 (HA)的含量 ,并观察其组织学改变的差异。结果 治疗组血清 AL T、AST、PC 、HA均显著低于模型组 (P<0 .0 5 )。病理学提示 ,治疗组肝细胞损伤、肝脏脂肪变性与纤维组织形成较少。结论 “抗纤汤”在抗纤维化治疗中有确切疗效。

Objective To study the effect of Kang Xian Soup to prevent liver fibrosis induced by carbon tetrachloride in rats.Methods 60 rats were divided randomly into three groups which were normal control group, model group and treatment group. The levels of serum ALT, AST, PCⅢ and HA were detected and pathologic changes of hepatic tissues were analyzed on the three groups.Results The levels of serum ALT, AST, PCⅢ and HA in the treatment group were notably lower than those of model group ( P <0 05) and the pathologic results under microscope were much better than model group. Hepatocyte damnify, adipohepar and fiber tissues of liver in the treatment group were fewer than model group. Conclusions Kang Xian Soup is an effective drug to prevent liver fibrosis.