^(18)F-FDG符合线路显像诊断乳腺癌

The study of ^(18)F-FDG DHC imaging used for diagnosing breast cancer

目的 探讨1 8F 脱氧葡萄糖 (FDG)符合线路 (DHC)显像诊断原发性乳腺癌及监测腋窝淋巴结转移的价值。方法 对 31例乳腺肿块患者行1 8F FDGDHC显像 ,其中 2 1例显像后行针刺活组织检查。结果 ① 31例中病理检查证实乳腺癌 2 6例 ,其中 2 1例乳腺癌原发灶1 8F FDG显像阳性 ,5例阴性。② 10例手术病理检查证实腋窝淋巴结转移 ,其中 3例1 8F FDGDHC显像腋窝淋巴结阳性 ,余 7例阴性。③行针刺活组织检查 2 1例中 13例找到瘤细胞。④1 8F FDGDHC显像诊断乳腺癌原发灶、乳腺癌腋窝淋巴结转移及针刺活组织检查诊断乳腺癌原发灶的灵敏度分别为 80 8%、30 0 %、72 2 % ,特异性分别为 5 5例、10 0 %、3 3例 ,准确性分别为 83 9%、77 4 %、76 2 %。⑤1 8F FDGDHC显像及针刺活组织检查诊断乳腺癌原发灶的灵敏度及准确性差异均无显著性 (P >0 0 5 )。结论 1 8F FDGDHC显像诊断乳腺癌原发灶的灵敏度和特异性较高。

Objective To explore the diagnostic value of 18 F-fluorodeoxyglucose (FDG) dual-head coincidence (DHC) imaging for detecting breast cancer and axillary lymph node metastases. Methods Thirty-one female patients were studied by 18 F-FDG DHC imaging, and 21 of them received fine needle aspiration biopsy after 18 F-FDG DHC imaging. The results of 18 F-FDG DHC imaging and fine needle aspiration biopsy were compared with those of histopathology. Results ①Among the 26 cases of breast carcinoma by 18 F-FDG DHC imaging, the FDG uptake of 21 cases showed positive. The lesion diameters ranged from 1.7～8 (mean 3.2±1.6) cm, the lesion/background (L/B) ratio range was 1.4～7.3 (mean 2.4±1.3). The other 5 malignancies were negative, their diameter range was 0.8～3.3 (mean 1.9) cm. ②Ten cases of the malignancies were confirmed with axillary lymph node metastases. Three cases by 18 F-FDG DHC imaging were positive. Those lymph node diameters were 1.4, 1.8 and 5.2 cm, respectively. The L/B ratios were 1.3, 1.5 and 6.2, respectively. The other 7 cases were negative. The lymph node diameter range was 0.2～1.8 cm. ③Twenty-one cases received fine needle aspiration biopsy . Tumor cells were found in 13 cases. ④The sensitivity, specificity and accuracy of 18 F-FDG DHC imaging for diagnosing primary breast carcinoma were 80.8%, 5/5 and 83.9%, respectively. The sensitivity, specificity and accuracy of 18 F-FDG DHC imaging for diagnosing lymph node metastases were 30.0%, 100% and 77.4%, respectively. The sensitivity, specificity and accuracy of fine needle aspiration biopsy for diagnosing primary breast carcinoma were 72.2%, 3/3 and 76.2%, respectively. ⑤There was no significant difference between the sensitivity of 18 F-FDG DHC imaging and fine needle aspiration biopsy (P>0.05). Conclusion 18 F-FDG DHC imaging possesses higher sensitivity and specificity in the diagnosis of breast cancer. It can be used as a noninvasive modality for evaluating breast cancer.