用SPECT断层显像体积积分法测定甲状腺质量

Determination of the mass of the thyroid by SPECT tomography image volume-integration

目的 用SPECT断层显像体积积分法 (简称断层积分法 )测定甲状腺质量。方法 通过自编SPECT断层积分软件和γ显像平面法对自制 39例甲状腺模型、19例正常甲状腺和 74例甲状腺功能亢进 (简称甲亢 )患者的甲状腺质量进行测定。结果 断层积分法计算甲状腺模型质量的误差为 (- 0 4 6± 6 39) %～ (1 34± 4 6 3) % ,平面法误差为 (- 16 0 2± 6 0 1) %～ (2 2 90± 10 4 2 ) % ;用断层积分法和平面法计算 19例正常甲状腺及 74例甲亢患者甲状腺的质量分别为 (2 2 5 6± 5 78)g和(2 9 16± 6 4 1)g(P <0 0 0 1) ,(38 78± 8 6 5 )g和 (4 4 90± 10 5 7)g(P <0 0 0 1)。结论 用断层积分法能精确测定甲状腺质量 ,有利于1 31 I治疗甲亢个体剂量最优化。

Objective To determine the thyroid mass by SPECT tomography image volume-integration for determining the therapeutic dose of radioiodine in patients with hyperthyroidism. Methods Thyroid mass was determined by self-produced SPECT tomography image volume-integration software and SPECT planar imaging in 39 thyroid models, 19 normal thyroids and 74 thyroids of hyperthyroidism. Results The errors of calculating the mass of thyroid models by tomography image volume-integration were merely (-0.46±6.39)%～(1.34±4.63)% whereas the errors of calculating by planar imaging were (-16.02±6.01)%～(22.90±10.42)%, the thyroid mass was (22.56±5.78) and (29.16±6.41) g (P<0.001), (38.78±8.65) and (44.90±10.57) g (P<0.001) by SPECT tomography image volume-integration and planar imaging in 19 normal thyroids and 74 hyperthroidism patients, respectively. Conclusion The thyroid mass was calculated precisely by SPECT tomography image volume-integration, its application is favourable for optimizing the 131 I dose for radiotherapy in patients with hyperthyroidism.