50岁以上房间隔缺损介入与外科治疗的对比研究

Comparison study between transcatheter closure and surgical repair in over 50-year old patients with secundum atrial septal defect

目的 探讨高龄继发孔房间隔缺损 (ASD)病人的最佳治疗方式。方法 收集 5年来 5 0岁以上继发孔ASD行常规外科手术修补 5 3例和同期经导管介入Amplatzer双盘封堵器堵闭ASD 4 2例的资料进行分析 ,两组病例均采用彩色多普勒超声心动图测量心尖四腔心的右室长径、肺动脉压、三尖瓣反流面积、左室舒张末内径 ,左室射血分数等进行对比。结果 外科手术组成功 5 2例 ,成功率 98 1% ,术后出现脑栓塞、心包积液等并发症 13例 ( 2 4 5 % ) ,死亡 1例 ( 1 9% )。导管介入组堵闭成功率 97 6 % ,仅 1例于术后第 4d封堵器脱落移位至肺动脉。两组术后超声心动图复查显示 ,右心室超负荷明显改善 ,右心腔缩小 ,肺动脉高压改善或消失 ;住院天数外科组为 ( 19 8± 12 2 3)d ;介入组 ( 5 0± 2 5 )d。结论 外科手术治疗ASD适应证范围较介入组宽 ,对合并心脏结构明显异常者 ,需行外科手术 ,方可矫正血流动力学异常。介入组术前病例选择非常重要 ,严格掌握适应证范围和尽可能准确地了解ASD的最大直径 ,恰当选择封堵器的大小极为重要 ,经筛选的高龄ASD病人应用经导管介入治疗成功率高、并发症少、疗效好 ,恢复得快。

Objective: The aim of this study is to compare the clinical data and result between transcatheter closure and surgical repair for the treatments of secundum ASD in patients above 50 years old, and explore the indications for these two methods. Methods: From January 1998 to December 2003, 53 patients with surgical repair and 42 patients with transcatheter closure were enlisted according to the diagnosis of ASD. The ages of all of cases were above 50 years old. The interventional approach was administrated with Amplatzer device. The surgical approach mended the defect directly or with autologous pericardium. These patients were followed up by echocardiography (Echo). The clinical data including the diameter of the right ventricle (RVD), the pulmonic flow velocity, the pulmonary pressure and the tricuspid valve regurgitation. Results: In surgery group, surgical mortality was 1 9% (1/53). Cerebral embolism occurred in 4 (7 5%) patients. Pericardial effusion and other complications occurred in 24.5%. All 42 patients with ASD were effectively closed with Amplatzer occlude. One occluder displaced and moved into pulmonary artery on the fourth day after the treatment. The short term effective rate was 97 6% in transcatheter closure group. The diameter of ASD showed by Echo was significantly less in patients treated with transcatheter closure than that in surgical repair group. The hospitalization time was significantly less in patients treated with transcatheter closure. The follow up data recorded decreased load of right ventricle, the decreased diameter of right ventricle as well as the relief of pulmonary artery hypertension. Conclusion: The data suggested that of surgical approach of ASD has a wider indication for patients in different stages of the disease, whereas surgical morbidity may increase in elderly patients due to their pre existed diseases. However, the transcatheter closure for ASD is feasible for patients with smaller defects.