可溶性耐药相关钙结合蛋白在乳腺癌组织中的表达及其与预后关系

The Prognostic Significance of Sorcin Expression in Primary Breast Carcinoma

目的:探讨可溶性耐药相关钙结合蛋白(Solubleresistance-relatedcalciumbindingprotein,Sorcin)在乳腺癌组织中的表达,评估其在乳腺癌预后中的作用。方法:采用免疫组织化学方法(IHC)检测60例手术切除的乳腺癌组织中Sorcin的表达,并分析其与临床、病理特征的关系及对预后的影响。结果:1)Sorcin在乳腺癌组织中的阳性表达率为56.7%(34/60);2)Sorcin与月经状况、肿瘤大小、淋巴结转移、组织分级和激素受体状况均无明显差异(P>0.05);3)Kaplan-Meier生存分析结果表明Sorcin表达与无瘤生存期和总生存期均无明显差异(P>0.05);4)COX单因素分析和多因素分析显示肿瘤大小、淋巴结转移和ER与无瘤生存期及总生存期(P<0.05)明显相关,PR与总生存期(P<0.05)明显相关。结论:Sorcin在乳腺癌组织中具有高表达,与乳腺癌的无瘤生存期和总生存期皆无明显差异。

Objective: To investigate the expression of Sorcin in primary breast cancer and determine whether such expression can predict survival. Methods: Expression of Sorcin in 60 breast cancer patients was determined by immunohistochemistry on formalin-fixed, paraffin-embedded tumor section. The relationship between the expression of Sorcin with the clinicophathological characteristics and the prognosis of breast cancer patients were also analyzed. Results: 1) Sorcin expression was observed in 34 of 60 (56.7%) cases. 2) No relation can be established between expression of Sorcin and clinicophathological parameters (P>0.05). 3) Kaplan-Meier analyses revealed that Sorcin expression didn't associated with disease-free survival (DFS) or overall survival (OS) (P>0.05). 4) In univariate and multivaiate COX regression analyses, tumor size, lymph node metastasis and estrogen receptor status were associated with DFS and OS (P<0.05). In addition, progestin receptor status was associated with OS (P<0.05). Conclusion: Sorcin is frequently expressed in primary breast carcinoma, but it isn't an independent predictive factor for DFS or OS.