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瘦素对大鼠离体胰岛β细胞胰岛素分泌和Kir6.2基因表达的调节 被引量：3

Regulation of leptin on insulin secretion and Kir6.2 mRNA expression in pancreatic islets of rats in vitro
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摘要 研究瘦素在不同的葡萄糖浓度下对离体大鼠 β细胞胰岛素分泌以及ATP敏感性K+ 通道(KATP)亚单位Kir6.2基因表达的调节及其可能的细胞内信号转导途径。结果表明在不同的葡萄糖浓度下 ,瘦素对胰岛素分泌的调节呈双向变化 ,对Kir6.2基因表达的调节可能通过细胞内与胰岛素受体底物 2有关的磷脂酰肌醇 3 Molecular mechanisms of leptin in regulating insulin secretion and expression of ATP-sensitive potassium channel subunit Kir6.2 mRNA and the possible signaling transduction pathway were investigated. Regulatory effects of leptin on insulin secretion could be biphasic at different glucose concentrations. The regulation of Kir6.2 transcript levels by leptin may be mediated through phosphatidylinositol 3-kinase signaling pathway.
作者 袁莉 安汉祥 邓秀玲 陈璐璐 李卓娅
机构地区 华中科技大学同济医学院附属协和医院内分泌科 德国肿瘤研究中心 华中科技大学同济医学院免疫学研究所
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2004年第3期268-270,共3页 Chinese Journal of Endocrinology and Metabolism
基金 教育部留学回国人员科学研究启动基金 (2 0 0 2 2 4 7) 湖北省自然科学研究基金 (2 0 0 2AB1 36)
关键词 瘦素 胰岛素 钾通道 信号转导 磷脂酰肌醇3-激酶 Leptin Insulin Potassium channels Signal transduction Phosphatidylinositol 3-kinase Rats, Sprague-Dawley
分类号 R58 [医药卫生—内分泌]
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共引文献9

同被引文献41

  • 1周张章,周才琼,赵国华,阚健全.瘦素与肥胖的关系[J].中国临床保健杂志,2005,8(1):85-87. 被引量：5
  • 2潘云龙,朱妍,施发兴,王晓玲,程英英,张真稳,王艳,陈晖.2型糖尿病患者血清Leptin浓度的变化及其与胰岛素抵抗、β-细胞功能的关系[J].实用临床医药杂志,2005,9(9):89-91. 被引量：6
  • 3李颖,刘东方.早相胰岛素分泌缺陷在2型糖尿病发病机制中的作用[J].重庆医学,2007,36(3):280-282. 被引量：8
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中华内分泌代谢杂志
2004年 第3期

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