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Graves病血清sCTLA-4与Th_1/Th_2细胞因子平衡偏离的关系 被引量：3

Relationship between soluble CTLA-4 and shift of serum Th_1/Th_2 cytokine balance in patients with Graves′ disease
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摘要 探讨Graves病 (GD)血清可溶性细胞毒性T淋巴细胞相关抗原 4(sCTLA 4)与Th1/Th2 细胞因子失衡的关系。结果显示sCTLA 4升高 ,IL 4明显降低 ,IFN γ无明显改变 ,IFN γ/IL 4升高 ,sCTLA 4与IL 4呈直线负相关。提示GD血清Th1/Th2 细胞因子失衡 ,呈Th2 低下型 ,与sCTLA The relationship between soluble cytotoxic T lymphocyte associated antigen-4 (sCTLA-4) and imbalance of Th 1/Th 2 cytokines was investigated in patients with Graves′ disease. The results showed that sCTLA-4 was increased, IL-4 decreased. IFN-γ did not significantly change, IFN-γ/IL-4 was raised and there was a negative linear correlation between sCTLA-4 and IL-4, suggesting that imbalance of serum Th 1/Th 2 cytokines with a decline in Th 2 cytokine was associated with increased sCTLA-4.
作者 林夏鸿 李希圣 林玲
机构地区 福建医科大学附属第二医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2004年第3期242-244,共3页 Chinese Journal of Endocrinology and Metabolism
关键词 GRAVES病 血清 SCTLA-4 TH1/TH2 细胞因子平衡偏离 Graves′ disease Th 1 cells Th 2 cells Cytotoxic T lymphocyte associated antigen-4
分类号 R581.1 [医药卫生—内分泌]
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参考文献7

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二级参考文献11

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共引文献10

同被引文献45

  • 1侯炜,夏冰,毛琳,袁岸龙,杨占秋.细胞毒T淋巴细胞相关抗原4基因多态性与汉族溃疡性结肠炎患者的相关性研究[J].中华消化杂志,2005,25(4):199-201. 被引量：4
  • 2翟芸,周钢桥,贺福初.CTLA-4基因多态性与自身免疫性疾病的相关性研究进展[J].军事医学科学院院刊,2006,30(2):191-194. 被引量：1
  • 3钱力,鲁继荣.我国北方地区小儿哮喘CTLA-4基因多态性的相关研究[J].中国妇幼保健,2007,22(25):3578-3579. 被引量：1
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引证文献3

二级引证文献14

中华内分泌代谢杂志
2004年 第3期

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