冠状动脉病变积分与脉压指数相关性研究

A study of the relationship between coronary artery score and pulse pressure index

目的 探讨冠状动脉病变积分 (CAS)与脉压指数 (PPI)的关系。方法 711例行冠状动脉造影者 ,其中男 4 70例 ,女 2 4 1例 ,年龄 30～ 82 (6 1± 8)岁。以标准Judkins法行冠状动脉造影术 ,计算机定量分析系统 (QCA)分析冠状动脉狭窄程度并计算CAS。标准台式水银血压计测定外周肱动脉收缩压 (SBP)和舒张压 (DBP) ,并计算脉压 (PP)及PPI。结果 年龄、性别、体重指数、SBP、PP、PPI、升主动脉根径 (Ao)、高血压病史、2型糖尿病病史、高密度脂蛋白胆固醇均与CAS有显著相关关系。经多因素Logistic回归分析显示 ,PPI和Ao这两个指标与CAS呈显著正相关 (β =0 0 4 1～ 0 14 9,P均为0 0 0 0 )。结论 PPI和Ao这两个指标与CAS密切相关 ,是冠心病发生发展的良好的预测指标 ,并可应用于临床指导冠心病危险人群的早期干预。

Objective To evaluate the relationship between the Coronary Artery Score (CAS) and pulse pressure index (PPI). Methods Coronary angiography was performed in 711 patients, of whom 470 were male and 241 female, and whose age ranged from 30-82 (61.28±8.44) years. Brachial systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (pp) and PPI were measured. The severity of coronary artery lesions was analyzed by quantitive computer analysis system (QCA) to acquire CAS. Results Age, sex, BMI, SBP, PP, PPI, Ao, the history of essential hypertention, the history of type 2 diabetes, HDL-C were significantly related to CAS. In a Logistic multivariate analysis, PPI and Ao were significantly related to CAS (β=0.041～0.149, P=0.000). Conclusion PPI and Ao are closely related to CAS. They are predictors for patients with coronary artery disease and the results can be used in clinical indication.