期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

糖基化终末产物、细胞外基质及药物的干预治疗 被引量：1

下载PDF
导出
摘要 在糖尿病患者体内，晚期糖基化终末产物(AGEs)的形成是糖尿病血管并发症终末产物发生、发展的启动因素，导致不同组织血管细胞外基质的重构，采用药物干预糖基化终末产物的形成和生物学效应，有助于防治上述病变。目前，药物的干预治疗研究主要集中于氨基胍、噻唑衍生物类、维生素类。
作者 李强翔 文格波
机构地区 南华大学附属第一医院临床研究所
出处 《美国中华临床医学杂志》 2004年第1期84-86,共3页 American Journal of Chinese Clinical Medicine
关键词 糖基化终末产物 细胞外基质 干预治疗 药物治疗 并发症 糖尿病
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献7

二级参考文献28

  • 1侯芳玉 李才 等.－[J].中国实验诊断学,1998,2(5):262-262.
  • 2Yokotama H, Deckert T. Central role of TGF-β in the path- ogenesis of diabetic nephropathy and macrovascular complication:a hypothesis[J]. Diabet Med, 1996, 13(4):313-320.
  • 3Wilson DP, Saward L, Zahradka P, Cheung PK. Angio- tensinⅡ receptor antagonists prevent neointimal proliferation in a porcine coronary artery organ culture model[J]. Cardiovasc Res, 1999, 42(3):761-772.
  • 4Horinchi S, Araki N, Morino Y. Immunochemical approach to characterize advanced glycation end products of the Maillard reaction. Evidence for the presence of a common structure[J]. J Biol Chem, 1991, 266(12):7329-7332.
  • 5Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria[J]. J Clin Invest, 1973, 52(11):2745-2756.
  • 6Kaneto H, Morrissey J, Klahr S. Increased expression of TGF-β1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation[J]. Kidney Int, 1993, 44(2):313-321.
  • 7Esposito C, Gerlach H, Brett J, Stern D, Vlassara H. Endothelial receptor-mediated binding of glucose-modified albumin is associated with increased monolayer permeability and modulation of cell surface coagulant properties[J]. J Exp Med, 1989, 170(4):1387-1407.
  • 8Stitt AW, Li YM, Gardiner TA, Bucala R, Archer DB, Vlassara H. Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats[J]. Am J Pathol, 1997, 150(2):523-531.
  • 9Ziyadeh FN, Han DC, Cohen JA, Guo J, Cohen MP. Glycated albumin stimulates fibronectin gene expression in glomerular mesangial cells: involvement of the transforming growth factor-β system[J]. Kidney Int, 1998, 53(3):631-638.
  • 10Anderson S. Role of local and systemic angiotensin in diabetic renal disease[J]. Kidney Int, 1997, 63(Suppl):S107-S110.

共引文献51

同被引文献13

  • 1齐向明,吴永贵,吴国仲,林辉,钱浩,郝丽.依那普利联合霉酚酸酯对大鼠糖尿病肾脏协同保护作用及机制[J].中华肾脏病杂志,2005,21(9):538-542. 被引量：9
  • 2李强翔,李玮,文格波,欧玉兰,刘江华,欧阳贵,黄凌云.氨基胍和维生素C对糖尿病大鼠血脂的影响[J].中国医师杂志,2006,8(1):13-15. 被引量：5
  • 3BUSCH M,FRANKES,WOLF G.et al.The advanced glycation end product N (epilon)-carboxymethyllysine is not a predictor of cardiovascular events and renal outcomes in patients type 2 diabetic kidney disease and hypertension[J].Am J Kidney Dis.2006; 48(4):571-579.
  • 4SOULIS-LIPAROTA T,COOPER M,PAPAZOGLM D,et al.Retardation by aminoguanidine of development of development of albuminuria,mesangial expansion,and tissue fluoresccnse in streptozotocin-induced diabetic rat[J].diabetes,1991,40:1328-1333.
  • 5GEMBAL,GOULD BJ.The effect of ascorbic acid on protein glycoslation in streptozotocin rats[J].diabetes,1992,41 (2):167-173.
  • 6Miyata T,Yamamoto M,Izuhara Y.From molecular footprints of disease to new therapeutic interventions in diabetic nephropathy[J].Ann N Y Acad Sci.2005; 1043:740-749.
  • 7SEBEKOVA K,GAZDIKOVA K,SYROVA D,et al.Effects of ramipril in nindiabetic nephropathy:improved parameters of oxidatives stress and potential modulation of advanction glycation end products[J].J Hum Hypertens.2003; 17(4):265-270.
  • 8TILTON RG,CHANG K,ALLISON W,et al.Glycosylation induced increases in blood flow and 125I-albamn permeation:role of nitric oxide and superoxide (abstract)[J].FASEB,1993,7(part Ⅱ):A905.
  • 9VLASSRA H.The AGE-receptor in the pathigenesis of diabetic complications.Diabetes[J].Metab Rev.2001,17(6):436-43.
  • 10FORBES JM,COOPER ME,THALLAS V,et al.Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy[J].Diabetes.2005(11):3274-82.

引证文献1

二级引证文献1

美国中华临床医学杂志
2004年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部