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病毒学研究的新工具:脱氧核酶及其应用 被引量:1

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摘要 脱氧核酶是利用体外分子进化技术 ,从随机脱氧核苷酸单链库中获得的一种具有酶活性的DNA分子。通过该技术已筛选出具有核酸酶活性、激酶活性、过氧化物酶活性等多种催化功能的脱氧核酶。本文概述了脱氧核酶的筛选方法、催化特点。
出处 《国外医学(病毒学分册)》 2004年第3期69-72,共4页 Foreign Medical Sciences(Section of Virology)
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  • 1Piedra PA. Respiratory syncytial virus vaccine: recent developments. Pediatr Infect Dis J. 2000. 19:805-808.
  • 2Santoro SW, Joyce GF. A general purpose RNA-cleaving DNA enzyme. Pro Nat] Acad Sci USA. 1997.94:4262-4266.
  • 3Player MR, Barnard DL, Torrence PF. Potent inhibition of respiratory syncytial virus replication using a2-SA-antisense chimera targeted to signals within the virus genomic RNA. Proc Natl Acad Sci USA, 1998, 95:8874-8879.
  • 4Cirino NM, Li G, Xiao W, et al. Targeting RNA decay with 2',5'oligoadenylate-antissense in respiratory syncytial virus -infected cells.Proc Natl Acad Sci USA. 1997.94:1937-1942.
  • 5Wu Y, Yu I, Mcmahon R, et al. Inhibition of bcr-abl oncogenr expression by novel deoxyribozyme. Hum Gene Ther, 1999, 10:2847 -2857.
  • 6Finkle E. DNA cuts its teeth-as an enzyme. Science, 1999, 286:2441-2442.
  • 7Lowe HC, Fahmy RG, Kavurma MM, et al. Catalytic oligodeoxynucleotides defme a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis.Circ Res , 2001,89:670-677.
  • 8Sriram B, Baneljea AC. In vitro-selected RNA cleaving DNA enzymes from a combinatorial library are potent inhibitors of HIV-1 gene expression. Biochem J, 2000, 352( Pt 3) :667-673.
  • 9Unwalla H, Banerjea AC. Inhibition of HIV-1 gene expression by novel macrophage-tropic DNA enzymes targeted to cleave HIV-1 TAT/Rev RNA. Biochem J, 2001, 357(Pt 1) :147-155.
  • 10Toyoda T, Imamura y, Takaku H, et al. Inhibition of influenza virus replication in cultured cells by RNA-cleaving DNA enzyme.FEBS Lett, 2000, 481:113-116.

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