大鼠颈髓膜表面短声诱发电位及起源

Click-Evoked Potentials on the Surface of the Cervical Dura Mater of Rat

目的 记录短声诱发的颈髓硬膜外电位 ,并初步证实其来源。方法 雄性Wistar大鼠 11只分为正常对照组 (n =5 )和阿米卡星给药组 (n =6 )。阿米卡星剂量为 4 0 0mg kg。动态检测用药后听阈 (ABR与高频测听 ) ,待听阈提高到 80dBSPL以上时 ,记录第三颈椎水平脊髓膜表面短声诱发电位。结果 阿米卡星破坏耳蜗后仍存在短声诱发的颈髓硬膜外电位 ,峰值潜伏期为 6 .13～ 7.0 8ms。结论 颈髓硬膜外记录到的短声诱发的电位来源于球囊 。

Objective To record the potentials evoked by click on the surface of the spinal cord and to elucidate its origins.Methods 11 male wistar rat were subdivided into 2 groups:normal control group( n=5 ) and Amicaxin group( n =6,intramuscularly 400 mg/kg/day).Dynamic auditory threshold was monitored(ABR and high frequency).The click-evoked potentials on the surface of cervical spinal cord at the 3 th cervical section was recorded when the auditory threshold rised up to 80 dB SPL.Results Click-evoked potentials on the surface of the cervical spinal cord still existed after damage of the cochlear function with a dministration of Amicaxin.The peak latency was 13～7.08 ms.Conclusion Click-evoked potentials on the surface of the cervical spinal cord of rat oringinated in the saccule and it will throw some light on the understanding of pathology associated with saccule,such as Meniere's disease and Tullio phenomenon.