摘要
目的制备复方克霉唑乳膏,并建立其质量控制方法。方法于乳膏基质中加入克霉唑、尿素,制得复方克霉唑乳膏,用二阶导数光谱法测定克霉唑含量。结果克霉唑在120～480μg/mL之间线性关系良好,平均回收率为99.37%,RSD为2.3%(n=9)。结论处方组成合理、制剂稳定,含量测定方法简便、准确。
Objective:To develop a preparation and quality control method for compound clotrimazole cream.Methods:The compound clotrimazole cream was prepared with clotrimazole,urea and cream base.The content of clotrimazole was determined by second-derivative spectrotometry.Results:Calibration curve of clotrimazole was linear in the range of 120～480 μg/mL.The average recovery was 99.37%,RSD=2.3%(n=9).Conclusion:This preparation was rational in design and stable in quality.The method of determination was simple,fast and accurate.
出处
《中国药业》
CAS
2004年第7期46-47,共2页
China Pharmaceuticals
关键词
克霉唑
尿素
乳膏
制备
含量测定
clotrimazole
urea
cream
preparation
quality control
