国产乙肝血源疫苗不同剂量免疫2年效果观察

TWO—YEAR OBSERVATION OF IMMUNIZATION OF CHINA-MADE HEPATITIS-B-VACCINE OF DIFFERENT DOSES

按0、1、6免疫程序,肌肉注射不同剂量(5、10、20μg)国产乙肝血源疫苗,观察其对HBV血清标志均阴性的152名健康学龄儿童的免疫效果。首针后2年,5、10,20μg各组的Anti—HBs应答半分别为88.9％、97.2％、87.2％;Anti—HBs GMT维持在85.7～1052S/N(166.1～322.1mIU/ml);Anti—HBsS/N≥10者三组分别占88.9％、91.7％、84.6％。疫苗组及对照组HBV感染率各为1.74％和32.4％,保护率是94.6％。疫苗接种者无严重不良反应。表明国产乙肝血源疫苗免疫效果确实,低剂量(5μg)用於健度儿童阻断水平传播是可行的。

In order to study the immunization of china-made hepatitis-Bvaccine, 152 seronegative school children in good health were vaccinated 5,10 or 20μg of hepatitis-B-vaccine according to immune pro- cedures of 0,1 end 6 months. After two years from the first injection, immune response rate of Anti-HBs GMT is between 85.7～105.2S/N (166.1—322.1mLU/ml). The children whose anti-HBs equal to or are more than 10S/N account for 88.9%, 91.7% and 84.6% respectively in the 5, 10 and 20μg groups. The infection rate of the vaccinated group is 1.74% and that of the control group 32.4%. The protective rate is 94.6%. There is no bad respondence in injected children, which shows that the effectiveness of hepatitis-B-vaccine is reliable. A small dose (5μg) is enough for blocking transverse transmisson among healthy children.