摘要
A mild and highly efficient synthesis of C7-C14 and C15-C21 fragments of epothilone B and D is described in which racemic C7-C14 fragment is prepared from nerol through four steps, and C15-C21 fragment is obtained from 1, 3-dichloroacetone, thioacetamide and propionaldehyde.
A mild and highly efficient synthesis of C7-C14 and C15-C21 fragments of epothilone B and D is described in which racemic C7-C14 fragment is prepared from nerol through four steps, and C15-C21 fragment is obtained from 1, 3-dichloroacetone, thioacetamide and propionaldehyde.
基金
the National Natural Science Foundation of China (No.20214),Ministry of Education
Natural Science Foundation and Education Commission of Hubei Province
