奥美拉唑与莫沙比利联合治疗反流性食管炎

Combined Treatment of Reflu Esophagitis with Omeprazole and Mosabilium

目的 总结奥美拉唑与莫沙比利联合治疗对反流性食管炎的临床疗效。方法 选择反流性食管炎 1 0 9例 ,随机抽取 5 5例为治疗组 ,采用奥美拉唑 2 0mg ,每早空腹口服 ,莫沙比利 5mg ,餐前 30min口服 ;另5 4例为对照组 ,采用西米替丁 2 0 0mg、莫沙比利 5mg ,3次 /d口服 ,连用 4周。进行疗效评价。结果 治疗组总有效率为 94 5 % ,对照组为 72 %。结论 奥美拉唑为质子泵制剂 ,可通过增强食管下括约肌张力 ,治疗反流性食管炎。

Objective To summarize the clinical effect on combined treatment of reflu esophagitis with omeprazole and mosabilium. Methods 55 cases were selected as therapy group randomly in 100 cases reflu esophagitis patient and 45 cases as control. The therapy group was treated with 20 mg omeprazole and 5mg mosabilium orally 30 min before meal. The control group was treated with 20 mg cimetidine and 5 mg mosabilium for 4 weeks as a course. The curative effect was assessed. Results The total curative rate were 94.5% in therapy group and 72% in control group. Conclusion Omeprazole as inhibitor of obligation pump could increase the tension of esophageal sphincter to control reflu.