兰索拉唑对预防脑梗死并发消化道出血的临床观察

Clinical Observation on Lansoprazole to Prevention Cerebral Infarction Combined with Digestive Hemorrhage

目的 探讨兰索拉唑对预防脑梗死并发消化道出血的作用。方法 选择脑梗死 72例 ,随机分成治疗组 38例 ,给兰索拉唑 30mg 1次 /d ,另外 38例为对照组 ,不采用任何预防消化道出血药物。结果 消化道出血发生率 ,治疗组为 7 1 4 % ,而对照组为 4 1 5 7% ,2组比较差异显著。结论 脑梗死并发消化道出血机率较高 ,兰索拉唑使质细胞的泌酸功能抑制 。

Objective To discuss the action of lansoprazole on prevention of cerebral infarction combined with digestive hemorrhage. Methods 72 cases of cerebral infarction patient were divided into two groups randomly, 38 cases of therapy group were treated with 30 mg/d and 38 cases of control group were taken as control. Results The incidence of digestive hemorrhage were 7.14% in therapy group and 41.5% in control group with significantly difference. Conclusion The chance of digestive hemorrhage was higher in cerebral infarction patient. Lansoprazole might inhibit acid secretion to prevent hemorrhage happening.