下咽癌组织Th1/Th2类细胞因子的表达及意义

The gene expression of Th1/Th2 cytokines and its role in hypopharyngeal carcinoma

目的 :检测下咽癌组织中辅助性T淋巴细胞 (Th) 1/Th2类细胞因子的表达 ,探讨其在下咽癌发生发展中的可能作用。方法 :采用逆转录聚合酶链反应 (RT PCR)技术 ,检测 5例正常人及 2 0例下咽癌组织中Th1/Th2类细胞因子的基因表达。结果 :2 0例下咽癌组织中 ,主导Th2类细胞因子的白细胞介素 (IL) 4和IL 10呈强势表达 ,而主导Th1类细胞因子的干扰素γ(IFN γ)和IL 2基本不表达或表达较弱。结论 :下咽癌组织Th2类细胞因子呈强势表达 ,可能是下咽癌患者免疫功能低下、促肿瘤生长的原因之一。

Objective:To observe the mRNA expression of Th1/Th2 cytokines in hypopharyngeal neoplasms and to explore the pathogenesis of it.Method:The gene expression of Th1/Th2 cytokines in patients with hypopharyngeal neoplasms was detected by RT PCR.Result:The cytokines expression of Th2 was significantly stronger than Th1 in tissue of hypopharyngeal carcinoma.Conclusion:The dominant expression of Th2 cytokines in hypopharyngeal neoplasms may inhibit the human immunity and enhance the growth and metastasis of hypopharyngeal carcinoma.