Fe^(3+)改性羧甲基纤维素对腹腔粘连预防作用的研究

Fe^(3+) modified sodium carboxymethyl cellulose in the prevention of abdominal adhesion

目的 探讨Fe3 + 改性羧甲基纤维素对术后腹腔粘连的预防作用。方法 将 2 4只大鼠随机分为A、B、C 3组 ,先行均制作肠粘连模型 ,取A组为对照组 ,B组、C组于腹腔内损伤部位分别注入羧甲基纤维素钠及Fe3 + 改性羧甲基纤维素 ,术后 10d处死动物 ,观察各组腹腔粘连情况。结果 C组轻微粘连 ,A组广泛粘连 ,致密。 3组粘连分级差异有显著性意义 (P <0 .0 1) ,结论 Fe3 + 改性羧甲基纤维素明显减轻术后腹腔粘连程度 。

Objective To determine the effectiveness of Fe 3+ modified sodium carboxymethyl cellulose in preventing postoperative intraperitoneal adhesion.Methods Fourteen Wistar rats of adhesion model were randomly divided into three groups:Group A served as control group;In group B and C,3%sodium carboxymethyl cellulose and 3% Fe 3+ modified sodium carboxymethyl cellulose were intraperitoneally into the injured areas respectiely.All animals were killed on the 10 thday after operation.Abolominal adhesion of each group was observed.Results There were statistical significant differences in the extent of adhesion among the three groups (P<0.01).In the group A,the abdominal adhesion was extensie and dense,while in the group C,the abdominal adhesion was mild.Conclusion Fe 3+modified sodium carboxymethyl cellulose can reduce the extent of postoperative abdominal adhesion obviously and is more satisfactory than sodium carboxymethyl cellulose (SCMC).