参胆合剂对阿尔茨海默病模型大鼠学习记忆的影响

Effect of mistura ginsenoside and choline on rat models of alzheimer’s disease

目的 观察参胆合剂 (MGC)对阿尔茨海默病 (AD)模型大鼠学习记忆的影响。方法 应用喹啉酸损毁老年大鼠双侧Meynert基底核 ,制备AD模型 ,一次性训练被动回避跳台实验和水迷宫空间分辨能力测试 ,研究大鼠学习记忆的改变。结果 高、低剂量MGC使AD大鼠在跳台中出现的错误反应次数 (ig 13d)和学会迷宫所需的训练次数 (ig ,16d)显著减少 ,其作用与 1,2 ,3,4四氢吖啶 (THA ,10mg·kg-1·d-1,ig)无明显差异 ,除外高剂量MGC学会迷宫所需的训练次数比THA显著减少。结论 MGC有改善AD学习记忆障碍的作用。

Objective: To observe the effect of Mistura Ginsenoside and Choline (GMC) on rat models of Alzheimer’s disease(AD). Methods: Bilateral NBM of elderly rats were damaged with quinolinic acid(150 nmol in 2 μl for each NBM), and the AD rat model was established. The single passive aviodance step-down training and water-maze spatial localization test were used to study the ability of learning and memory in rats. Results: Treated with low and high dosages of GMC, AD rat models decreased significantly in the number of errors in step-down (ig for 13 days) and the times training to reach the criterion in water maze task (ig for 16 days). Except for the fact that the times of training to reach the criterion with high dosage of GMC were those than that with 1,2,3,4 tetrahydroacridine (THA, 10 mg·kg -1·d -1,ig), there was no obvious diffence in the effects of low, high dosage of GMC and THA. Conclusion: MGC can improve the disorder of learning and memory in AD rat models.