分子伴侣的多重功能(英文)

The mutifunction of chaperones

分子伴侣是一类能帮助其他蛋白质进行正确折叠、组装、转运、介导错误折叠的蛋白质进行降解的蛋白质。它们还参与染色体的复制、抗原的加工与提呈 ,并作用于一些信息转导分子以调节生长和发育。分子伴侣发挥功能依赖于ATP的结合与水解。热休克应答是生物界从细菌到植物和动物普遍存在的 ,它是保护细胞免受像热休克、酒精、能量代谢抑制剂、重金属、抗原加工与提呈、凋亡等有害环境损伤的一个基本的防御机制。这些蛋白质的相对水平是非常重要的 ,过多或过少的Hsp70或Hsp90可以导致生长异常、发育畸形甚至细胞死亡。

Moleculer Chaperones are proteins that can help target protein to acquire one possible conformation, translocation, refolding of intermediates, chromosome replication, proteases, such as the ubiquitin-dependent proteasome, ensure that damaged and short-lived proteins are degraded efficiently.They can also interact with multiple key components of signaling pathways that regulate growth and development. They function in ATP binding and hydrolysis. Heat shock response is ubiquitous and highly conserved-in all organisms from bacteria to plants and animals-as an essential defense mechanism for protection of cells from a wide range of harmful conditions, including heat shock, alcohols, inhibitors of energy metabolism, heavy metals, oxidative stress, antigen processing and presentation, apoptosis. The relative levels of these proteins may be important, as too little or too much Hsp70 or Hsp90 can result in aberrant growth control, developmental malformations and cell death.