长期服用小剂量阿司匹林对老年人大肠息肉生长的影响

Effect of low-dose aspirin use on large intestine polyps in elderly

目的 :了解老年人使用小剂量阿司匹林对大肠息肉生长的影响。方法 :回顾性分析 5 2例长期服用小剂量阿司匹林的老年人服用前后结肠镜检查结果 ,并与 6 3例未服用阿司匹林的老年人进行对照分析。结果 :服用小剂量阿司匹林 4～ 6年大肠息肉年负荷明显低于服用前 [( 1.3± 1.8)对 ( 2 .9± 5 .2 )mm/year,P <0 .0 5 ],服用时间≤ 2年 [( 2 .6± 6 .6 )mm/year]、2年 <服用时间≤ 4年 [( 2 .0± 3.8)mm/year]大肠息肉年负荷与服用前比较无显著性差异 (P >0 .0 5 )。结论 :老年人服用小剂量阿司匹林远期可抑制大肠息肉生长。

Objective:To investigate effect of low-dose aspirin use on large intestine polyps in elderly.Methods:52 subjects using low-dose aspirin and 63 controls were analyzed retrospectively according to colonoscopy examination results. Results:Large intestine polyp burden per year in subjects using low-dose aspirin for 4～6 years was lower significantly than that in subjects before using aspirin [(1.3±1.8)vs(2.9±5.2)mm per year, P <0.05 ].The polyp burden after using aspirin for 0～2 years [(2.6±6.6)mm per year]and 2～4 years[(2.0±3.8)mm per year] was not different in comparison with that before using aspirin respectively( P >0.05).Conclusions:Long-term low-dose aspirin use in elderly can inhibit growth of large intestine polyps.