强酸性离子交换膜催化合成5-乙氧羰基-4-(4-甲氧苯基)-6-甲基-3,4-二氢嘧啶-2(1H)-酮

Synthesis of 5-ethoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one by Catalysis of Strong Acidic Ion-exchange Membrane

在HF-101强酸性离子交换膜的存在下,由茴香醛、乙酰乙酸乙酯与脲一步合成了5 乙氧羰基 4 (4 甲氧苯基) 6 甲基 3,4 二氢嘧啶 2(1H) 酮。当茴香醛、乙酰乙酸乙酯与脲的摩尔比为1:2:5,乙醇作溶剂,4g离子交换膜,回流2h,产物收率达95 2%。同时研究了离子交换膜作为催化剂的重复使用情况。

5-ethoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydro-pyrimidin-2(1H)-one was synthesized from anisaldehyde, ethyl acetoactate, and urea in presence of HF-101 strong acidic ion-exchange membrane. The yield of the 3,4-dihydropyrimidin-2(1H)-one was up to 95.2% under the optimum cordition: moler ratio of anisaldehyde, ethyl acetoactate and urea 1:2:5, ion-exchange membrane 4 g, ethyl alcohol as solvent and refluxing for 2 h. The reusability of the catalyst was studied.