摘要
目的 观察和评估含阿米卡星及左氧氟沙星联合化疗方案在耐多药肺结核治疗中的疗效。方法 将 97例耐多药肺结核患者分为治疗组 4 8例和对照组 4 9例 ;化疗方案 :治疗组以阿米卡星及左氧氟沙星为主 ,联合利福喷丁、异烟肼对氨基水杨酸钠、丙硫异烟胺、吡嗪酰胺 ;对照组用阿米卡星、利副喷丁、异烟肼对氨基水杨酸钠、丙硫异烟胺、吡嗪酰胺 ,疗程为 2 1月。结果 共有 93例患者完成化疗疗程。治疗组 4 6例 ,痰菌阴转率 87% ;对照组 4 7例 ,痰菌阴转率 5 9.6 % ;痰菌阴转率治疗组明显高于对照组 (P <0 .0 1) .结论 含阿米卡星及左氧氟沙星方案治疗耐多药肺结核有助于痰菌阴转和病变吸收好转 ,药物不良反应低 。
Objective To observe and evaluate the treatment effect of the regimen which contains the Amikacin (AK) Sulfate and the Lexofloxacin (LVFX) for MDR-TB cases.Methods 97 MDR-TB patients were randomly divided into two groups.48 cases in the observation group (treated with AK,LVFX,DL-473,Pa,PZA,Pt),49 cases in the control group (treated with AK,DL-473,Pa,PZA,Pt).The duration of treatment was 21 months.Results 93 cases completed their treatment.The sputum smear negative conversion rate was 87% and 59% in the observation group (46 cases) and control group (47 cases).The rate in observation group was significantly higher than that of the control group (P< 0.01).Conclusion The regimen which contains Amikacin Sulfate and Levofloxacin was helpful to the sputum smear negative conversion and the absorption of the athology and with lower side reaction,this regimen deserve to be popularized in the practice.
出处
《中国防痨杂志》
CAS
北大核心
2004年第3期165-167,共3页
Chinese Journal of Antituberculosis