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心肌缺血/再灌注损伤中IGF的抗凋亡机制 被引量：1

The Antiapoptosis Mechanism of IGFs during Myocardial Ischemia/Reperfusion Injury
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摘要 胰岛素样生长因子对心肌缺血-再灌注损伤具有保护作用,它是通过代谢机制和细胞信号转导机制发挥抗心肌细胞凋亡的作用,现就其生理特点,对心肌的保护及抗凋亡机制进行综述。
作者 曾金 闵苏
机构地区 重庆医科大学附一院麻醉科
出处 《国外医学（麻醉学与复苏分册）》 2004年第3期129-131,共3页 Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
关键词 心肌缺血 再灌注损伤 IGF 抗凋亡机制 胰岛素样生长因子
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献20

  • 1Kovacs P, Bak I, Szendrei L, et al. Non-specific caspase inhibition reduces infarct size and improve post-ischemic recovery in isolated ischemial reperfusion rat hearts. Nunny-Schmiedebergs-Arch-Pharmacol, 2001, 364(6):501-507.
  • 2Villaveencio A, Iniguez G, Johnson MC, et al. Regulation off steroid synhesis and apoptosis by insulin-like grow~ I and insulin-like growth factor binding protein 3 in human corpus luteum during the midluteal phase. Reproduction, 2002, 124: 501-508.
  • 3Maggie M YC, Amanda L S, Kelle H S. High insulin-like growth factor I (IGF-I) and insulin concentration trigger apoptosis in the mouse blastocyt via down-regulation of IGF-I receptor. Endocrology, 2000, 141: 4784-4792.
  • 4Du XL, Sui GZ, Stickklouser FK, et al. Introduction of apotnsis by high proinsulin and gluocose in cultured human umbilical vein endothelial cell is mediated by reactive oxygen species. Diabetologia, 1998,41 (3): 2A9-256.
  • 5Baixerab E, Jeay S, Kedy PA, et al. The profilative and antiapoptotic actions of growth hormone and insulin-like growth factor-Ⅰ are mediated through distinct signaling pathways in the Pro-B Ba/F3 cell line. Endocrinology, 2001,142 (7): 2968-2977.
  • 6Grellier P, Berrebiz D, Puchuaur M, et al. The IGF system in neuroblastoma xenografts focus on IGF-binding protein-6. J-Emlocrinol, 2002, 172(3):467-476.
  • 7Allan GJ, Flint QJ, Patel K, et al. Insulin-like growth factor axis during embryonic development. Reproduction,2001,122(1):31-39.
  • 8Sciaccal MC, Panelinis G. In IGF-I receptor deficient leiomyosarcoma cell invasion and protection from apoptnsis via the insulin receptor isoform A.Oncogene, 2002,21 (54): 8240-8250.
  • 9Fujio Y, Nguyen T, Wencker D. Akt promotes survival of cardio myocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.Circulation, 2000,101:660-667.
  • 10Yeshi R, Tomms F. Effect of multiple phosphorylation events on the transcription factor FKHR, FKHRL1 and AFX. Biochem-Soc-Frans,2002,30(4):391-397.

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国外医学（麻醉学与复苏分册）
2004年 第3期

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